Uncovering the Biology of Long COVID

Distinguishing features of Long COVID identified through immune profiling

Some people develop post-acute infection syndromes (PAIS) after recovering from viral diseases like COVID-19, resulting in symptoms known as “Long COVID” (LC), including fatigue and cognitive issues. A study involving 273 individuals, some with LC and some without, used immune profiling and machine learning to identify differences. LC individuals showed unique immune responses, including exaggerated reactions to SARS-CoV-2 and higher responses to other viruses like Epstein-Barr. Cortisol levels were also lower in LC patients. These findings offer insights into LC’s biology and potential biomarkers.

Klein, J., Wood, J., Jaycox, J. et al. Distinguishing features of Long COVID identified through immune profiling. Nature (2023). https://doi.org/10.1038/s41586-023-06651-y


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