Reductive carboxylation epigenetically instructs T cell differentiation
Immune cells called CD8+ T cells play a crucial role in protecting the body from diseases like cancer by undergoing metabolic changes when activated. Researchers found that one specific metabolic process involving a mitochondrial enzyme called IDH2 affects the development of memory CD8+ T cells. Inhibiting IDH2 during the creation of CAR T cells enhances their effectiveness against cancers like melanoma and leukemia by promoting memory T cell features. This discovery suggests a way to improve CAR T cell therapy.
Jaccard, A., Wyss, T., Maldonado-Pérez, N. et al. Reductive carboxylation epigenetically instructs T cell differentiation. Nature (2023). https://doi.org/10.1038/s41586-023-06546-y