Boosting Immune Memory for Enhanced Cancer Therapy

Reductive carboxylation epigenetically instructs T cell differentiation

Immune cells called CD8+ T cells play a crucial role in protecting the body from diseases like cancer by undergoing metabolic changes when activated. Researchers found that one specific metabolic process involving a mitochondrial enzyme called IDH2 affects the development of memory CD8+ T cells. Inhibiting IDH2 during the creation of CAR T cells enhances their effectiveness against cancers like melanoma and leukemia by promoting memory T cell features. This discovery suggests a way to improve CAR T cell therapy.

Jaccard, A., Wyss, T., Maldonado-Pérez, N. et al. Reductive carboxylation epigenetically instructs T cell differentiation. Nature (2023).

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