Metformin improves boar sperm quality via 5′-AMP-activated protein kinase-mediated energy metabolism in vitro


Sperm requires ATP to function. The study decided to see if metformin, which activates 5′-AMP-activated protein kinase, would improve sperm function, specifically in boars. They found that metformin treated sperm had improvement in “sperm motility parameters, mitochondrial membrane potential, ATP content, p-AMPK, glucose uptake, and lactate efflux.”

TL;DR Metformin (typically a diabetic medication) improves the performance of boar sperm

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