Final analysis of the CLL2-GIVe trial: obinutuzumab, ibrutinib, and venetoclax for untreated CLL with del(17p)/TP53mut

ByThe Short Paper

This study explored a treatment combination (obinutuzumab, ibrutinib, and venetoclax) for a specific type of leukemia (chronic lymphocytic leukemia with del(17p) and/or TP53 mutation) in previously untreated patients. The treatment involved several cycles and aimed to achieve complete remission.

The results showed that 58.5% of patients achieved complete remission, and after around 3 years, the progression-free survival rate was 79.9%, with an overall survival rate of 92.6%. Some patients experienced side effects like neutropenia, infections, and cardiovascular issues, but these generally decreased over time.

In summary, this treatment regimen appears promising for high-risk chronic lymphocytic leukemia patients with manageable side effects.

Similar Posts

Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke The OPTIMAL-BP Randomized Clinical Trial

ByThe Short Paper

OPTIMAL-BP trial compared intense vs. conventional blood pressure lowering after stroke thrombectomy. The study asked whether aggressively lowering blood pressure shortly after successfully opening blocked blood vessels in acute stroke patients is beneficial. They found that 39.4% of patients with aggressive blood pressure management (aiming for lower levels) achieved functional independence after three months, compared…

Vitamin D insufficiency as a potential culprit in critical COVID-19 patients

ByThe Short Paper

Article They looked at the mean vitamin D serum level of 1,368 patients. The study found 634 patients with poor prognosis and 669 patients with good prognosis. Patients with a poor prognosis  had much lower serum levels of vitamin D than compared to those with good prognosis; this was statistically significant. TL;DR Patients with a…

Global Increase in Wildfire-Driven Air Pollution and Its Impact on Human Health

ByThe Short Paper

Global population exposure to landscape fire air pollution from 2000 to 2019 Wildfires, worsened by climate change, are becoming more severe and frequent. The smoke they produce, which can harm human health, hasn’t been well understood globally. Using advanced models and machine learning, scientists estimated that from 2000 to 2019, people around the world were…

Simple Summary – Effects of Intermittent Fasting on Health, Aging, and Disease

ByThe Short Paper

Link to the article: https://www.nejm.org/doi/full/10.1056/NEJMra1905136 This is a review paper where they reviewed the available literature concerning intermittent fasting. Going straight to the conclusion, preclinical and clinical trials show positive effects on patients, specifically those with obesity, diabetes, cancer, cardiovascular disease, and neurologic disorder. Animal models have shown to have positive results involving their health. Most…

Fasting-mimicking diet and hormone therapy induce breast cancer regression

ByThe Short Paper

Article In a mouse model, this study demonstrated that receptor positive breast cancer are affected by a fasting diet. This is effected by decreasing certain hormones (insulin, leptin, etc.). They found combined with a specific treatment (oestrogen therapy) a fasting like diet further decreased these hormones that are negatively associated in these cancers. TL;DR A…

Simple Summary – COVID-19 Fatalities, Latitude, Sunlight, and Vitamin D

ByThe Short Paper

Link to the article: https://pubmed.ncbi.nlm.nih.gov/32599103/ Vitamin D has been found to be important for the immune system and typically equator countries tend to have a higher dose due to their location. Looking at 88 countries and available data, they found there was a relationship between latitude and COVID-19 deaths consistent with previous literature. Populations at risk…