Mixed Outcomes Revealed in Early Metformin Treatment in Gestational Diabetes

Early Metformin in Gestational Diabetes

This study aimed to determine whether early initiation of metformin could improve outcomes for gestational diabetes. The research found that early treatment with metformin did not significantly reduce the need for insulin initiation or improve fasting hyperglycemia. However, certain secondary outcomes, such as maternal glycemic control and gestational weight gain, favored the metformin group, while neonatal outcomes showed smaller birth weights in the metformin group.

Dunne F, Newman C, Alvarez-Iglesias A, et al. Early Metformin in Gestational Diabetes: A Randomized Clinical Trial. JAMA. Published online October 03, 2023. doi:10.1001/jama.2023.19869


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