Single-Dose Psilocybin Treatment for Major Depressive Disorder

ByThe Short Paper

One-time psilocybin treatment for depression

A study investigated the effectiveness and safety of psilocybin, a compound found in certain mushrooms, for treating major depressive disorder. In a controlled trial with 104 adults, a 25-mg dose of psilocybin, when combined with psychological support, resulted in a significant and enduring improvement in depressive symptoms compared to a placebo. Importantly, no severe adverse events related to the treatment were observed. This suggests that psilocybin, administered under proper guidance, holds promise as a potential treatment for major depressive disorder.

Raison CL, Sanacora G, Woolley J, et al. Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial. JAMA. 2023;330(9):843–853. doi:10.1001/jama.2023.14530

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