Study on Dexamethasone for Tuberculous Meningitis in HIV Patients

This was a double-blind, randomized trial involving HIV-positive adults with tuberculous meningitis in Vietnam and Indonesia examined the effectiveness of dexamethasone, an anti-inflammatory drug, as an adjunct treatment. Participants received either dexamethasone or a placebo in addition to antituberculosis therapy. The study found that dexamethasone did not significantly improve survival rates or secondary outcomes, such as immune reconstitution inflammatory syndrome. The incidence of serious adverse events was similar between the two groups. The results suggest limited benefits of dexamethasone as an adjunctive treatment for this condition.


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