CD300ld on neutrophils is required for tumour-driven immune suppression
In cancer, the immune system often gets suppressed, making it hard to treat. Scientists have found a molecule called CD300ld that is important for this suppression. When they blocked CD300ld in mice with tumors, it made the tumors shrink and improved the immune system’s ability to fight the cancer. This discovery could be a promising target for cancer treatment in the future.
Wang, C., Zheng, X., Zhang, J. et al. CD300ld on neutrophils is required for tumour-driven immune suppression. Nature (2023). https://doi.org/10.1038/s41586-023-06511-9