Unlocking Genetic Diversity and Insights from the Mexico City Prospective Study

Genotyping, sequencing and analysis of 140,000 adults from Mexico City

The Mexico City Prospective Study, consisting of over 150,000 adults from urban districts in Mexico City, has provided valuable genetic data. Researchers generated genetic information for all participants, including exome sequencing for everyone and whole-genome sequencing for nearly 10,000 individuals. They discovered significant differences in ancestry composition and relatedness among participants, with most having mixed Indigenous American, European, and African heritage, influenced by various Indigenous populations across Mexico. Interestingly, Indigenous Mexican genome segments exhibited unique characteristics, such as lower coding variation and an excess of specific genetic changes. The study estimated allele frequencies for over 142 million genetic variants, primarily benefiting individuals with Indigenous Mexican ancestry. This research offers essential genetic resources for future studies in Mexico and the United States, particularly among the Mexican-descent Hispanic/Latino population.

Zhang, F., Zhang, B., Wang, Y. et al. An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption. Nature (2023). https://doi.org/10.1038/s41586-023-06611-6


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