Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia This clinical trial investigated whether inhaled amikacin, an antibiotic, could reduce the incidence of ventilator-associated pneumonia in critically ill patients on mechanical ventilation for at least 3 days. The study included 847 patients who received either inhaled amikacin or a placebo for 3 days. Results showed that inhaled amikacin…
This was a double-blind, randomized trial involving HIV-positive adults with tuberculous meningitis in Vietnam and Indonesia examined the effectiveness of dexamethasone, an anti-inflammatory drug, as an adjunct treatment. Participants received either dexamethasone or a placebo in addition to antituberculosis therapy. The study found that dexamethasone did not significantly improve survival rates or secondary outcomes, such…
Extracorporeal Life Support in Infarct-Related Cardiogenic Shock A multicenter trial examined the use of extracorporeal life support (ECLS) in patients with acute myocardial infarction complicated by cardiogenic shock. The study found that ECLS therapy did not significantly reduce the risk of death at 30 days compared to those who received medical therapy alone. However, ECLS…
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality A global study analyzed data from over 1.5 million participants to assess the impact of five modifiable risk factors (body-mass index, blood pressure, cholesterol levels, smoking, and diabetes) on cardiovascular disease and overall mortality. The research found that these risk factors are associated with…
