Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

Nirmatrelvir is a medication used to treat COVID-19. However, researchers were previously uncertain about how the virus could develop resistance to it. Recent findings have revealed that the virus can undergo two distinct changes to resist the medication. Some of these changes hinder the medicine’s effectiveness, while others make the virus more resilient. These combined alterations enable the virus to persist even when the medication is intended to inhibit it. Similar patterns were observed with another medication known as ensitrelvir. This newfound knowledge has the potential to assist scientists in designing improved medications in the future.

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