Boosting Immune Memory for Enhanced Cancer Therapy

ByThe Short Paper

Reductive carboxylation epigenetically instructs T cell differentiation Immune cells called CD8+ T cells play a crucial role in protecting the body from diseases like cancer by undergoing metabolic changes when activated. Researchers found that one specific metabolic process involving a mitochondrial enzyme called IDH2 affects the development of memory CD8+ T cells. Inhibiting IDH2 during…

Final analysis of the CLL2-GIVe trial: obinutuzumab, ibrutinib, and venetoclax for untreated CLL with del(17p)/TP53mut

ByThe Short Paper

This study explored a treatment combination (obinutuzumab, ibrutinib, and venetoclax) for a specific type of leukemia (chronic lymphocytic leukemia with del(17p) and/or TP53 mutation) in previously untreated patients. The treatment involved several cycles and aimed to achieve complete remission. The results showed that 58.5% of patients achieved complete remission, and after around 3 years, the…