Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke The OPTIMAL-BP Randomized Clinical Trial

ByThe Short Paper

OPTIMAL-BP trial compared intense vs. conventional blood pressure lowering after stroke thrombectomy. The study asked whether aggressively lowering blood pressure shortly after successfully opening blocked blood vessels in acute stroke patients is beneficial. They found that 39.4% of patients with aggressive blood pressure management (aiming for lower levels) achieved functional independence after three months, compared…

Final analysis of the CLL2-GIVe trial: obinutuzumab, ibrutinib, and venetoclax for untreated CLL with del(17p)/TP53mut

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This study explored a treatment combination (obinutuzumab, ibrutinib, and venetoclax) for a specific type of leukemia (chronic lymphocytic leukemia with del(17p) and/or TP53 mutation) in previously untreated patients. The treatment involved several cycles and aimed to achieve complete remission. The results showed that 58.5% of patients achieved complete remission, and after around 3 years, the…

Antibiotic Prophylaxis in Infants with Grade III, IV, or V Vesicoureteral Reflux

ByThe Short Paper

This study looked at the use of continuous antibiotic treatment to prevent urinary tract infections (UTIs) in infants with severe vesicoureteral reflux (a condition where urine flows back from the bladder to the kidneys). The study involved infants aged 1 to 5 months who had not had a UTI before. The results showed that those…