Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

Nirmatrelvir is a medication used to treat COVID-19. However, researchers were previously uncertain about how the virus could develop resistance to it. Recent findings have revealed that the virus can undergo two distinct changes to resist the medication. Some of these changes hinder the medicine’s effectiveness, while others make the virus more resilient. These combined…

Food Insecurity Is Associated With Higher Health Care Use And Costs Among Canadian Adults

Article The researchers looked at Canadian hospital and healthcare expenditure records. They looked at specific characteristics of patients specifically acute care hospitalization, same-day surgery, and acute care costs among Canadian adults. Patients who were more food insecure were more likely to be admitted for acute care as well as having surgery. They  found that patients…

Evaluating Coca-Cola’s attempts to influence public health ‘in their own words’: analysis of Coca-Cola emails with public health academics leading the Global Energy Balance Network

Article Using the Freedom of Information Act, researchers were able to obtain 18,030 pages of emails between Coca-Cola and West Virginia University and University of Colorado. The company attempted to fund research through various methods to obscure their relationship to the funding; even withholding information that Coca-Cola was behind the funding.  Researchers also found documentation of pushing…

Metformin improves boar sperm quality via 5′-AMP-activated protein kinase-mediated energy metabolism in vitro

Article Sperm requires ATP to function. The study decided to see if metformin, which activates 5′-AMP-activated protein kinase, would improve sperm function, specifically in boars. They found that metformin treated sperm had improvement in “sperm motility parameters, mitochondrial membrane potential, ATP content, p-AMPK, glucose uptake, and lactate efflux.” TL;DR Metformin (typically a diabetic medication) improves…

Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: the Hisayama Study

Article The study followed 1,892 Japanese people aged 40-79 over the course of 14 years. 280 people over that time period developed diabetes type II. They found that those that had the highest fiber intake had about half the likelihood of developing (0.53) diabetes compared to those who had the lowest fiber intake. They found…

Potently neutralizing and protective human antibodies against SARS-CoV-2

Article The study looked at COVID-19 antigens, specifically the ones related to a “spike” antigen that interacts with ACE2 and helps to infect people. The antibodies specifically were made to prevent interaction of the spike and ACE2. The antibodies were  COV2-2196 and COV2-2130. They were found to act in a synergistic manner with one another. In…

Bicycle-related injuries in the emergency department: a comparison between E-bikes and conventional bicycles: a prospective observational study

Article The study looked at 78 e-bikers and 91 conventional bikers and looked at their injuries. They found that mechanism of injury and general severity was the same for both groups. However, two e-bikers had the most severe injury. They also found that alcohol was consumed twice as often for conventional bikers. TL;DR People who…

Obesity and mortality of COVID-19. Meta-analysis

Article This meta analysis looked at 14 papers out of 572 publications for analysis. They looked at characteristics of patients including ” age, gender, body mass index, severe comorbidities, respiratory support and the critical illness related mortality in COVID.” They found all the characteristics are associated with COVID-19 except for gender. TL;DR Obese people have a higher…

SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity

Article 967 subjects were tested for IgG antibodies against COVID-19. They multiple subgroups of suspected cases, healthy donors, patients with rheumatic disease, and patients positive for polymerase chain reaction. They found PCR and IgG were in agreement in 83% of samples.  The levels of IgG and IgM levels were measured and found to not associate with…

A Multifactorial Approach to Overuse Running Injuries: A 1-Year Prospective Study

Article The prospective study looked at 76 runners, males and females. They kept a running diary for 1 year and were monitored injuries during this time period.   They found injured males tended to be heavier, had greater weekly distances, and greater side to side acceleration. Injured females tended to be heavier, longer flight times, and…