Link to the article: https://pubmed.ncbi.nlm.nih.gov/32584464/ They reviewed 57 papers looking at the sensitivity and specificity of their testing. They found that testing was useful early on but was useful after >15 days. After 35 days, data is limited and so using it determine prevalence in the general population is limited. Data available is limited and selective…
Link to the article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302353/ MicroRNA can have suppressive effects on certain biochemical pathways involved in cancer specifically osteosarcoma in regards to this paper. Using bioinformatics techniques, they were able to hone into specific miRNA that can suppress osteosarcoma. TL;DR Increases in certain molecular mechanisms can help suppress bone cancer (osteosarcoma)
Link to the article: https://pubmed.ncbi.nlm.nih.gov/32582383/ This article talks about slipped capital femoral epiphysis (SCFE) and the possible causes of it. One of which is a high BMI. They looked at 68 healthy hips/subjects. They found there was a correlation between BMI percentile and decreased epiphyseal tubercle size which is a factor contributing to reduced epiphyseal stability. TL;DR…
Disclaimer: I do not have a background in finance. I do have a background in medicine. I’m writing about CAR-T cell therapy because it’s been something I’ve been interested in for a while. I am not sure what impact it will have on biotech stocks or company valuations, but I believe it could be significant….
Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959807 This was a 2018 review of the literature out there for intermittent fasting. They reviewed clinical trials and performed a literature search looking for anything related to intermittent fasting starting from 1970 to 2018. Similar to the paper previously summarized the previous day, they concluded a variety of benefits for intermittent fasting. These…
Link to the article: https://www.nejm.org/doi/full/10.1056/NEJMra1905136 This is a review paper where they reviewed the available literature concerning intermittent fasting. Going straight to the conclusion, preclinical and clinical trials show positive effects on patients, specifically those with obesity, diabetes, cancer, cardiovascular disease, and neurologic disorder. Animal models have shown to have positive results involving their health. Most…
Link to the article: https://www.ncbi.nlm.nih.gov/pubmed/30099000 There’s a link between exercise and improved physical health. However, there has not been literature that has strongly supported the link between exercise and improved mental health. Using survey data from the Behavioral Risk Factor Surveillance System, the researchers analyzed patient mental health in a population of over a million. People who…
Link to the article: https://www.nejm.org/doi/full/10.1056/NEJMoa1817073 There is a standard of care in the treatment of chronic lymphocytic leukemia (CLL), a blood cancer common in the older population. The standard of care is the usage of fludarabine, cyclophosphamide, and rituximab; however there is a new treatment that may improve outcomes. This study looks at the usage of ibrutinib-rituximab….
Link to the article: https://www.nejm.org/doi/full/10.1056/NEJMoa1803185 This study revolves around the usage of a point of care test to guide antibiotic usage in patients with chronic obstructive pulmonary disease (COPD). They tested C-reactive protein (CRP) in patients with COPD. CRP is a inflammatory marker and increased levels are associated with worsening COPD. The study had two groups…
Link to the article: https://www.nejm.org/doi/full/10.1056/NEJMoa1900100?query=featured_home Similar to the last article, it’s been known that the WHO has specific transfusion guidelines which parts of Africa follows. In patients with severe anemia, red blood cells are transfused at a flat rate of 20 ml per kilogram of body weight. Although this transfusion rate is not in line with…
