Genotyping, sequencing and analysis of 140,000 adults from Mexico City The Mexico City Prospective Study, consisting of over 150,000 adults from urban districts in Mexico City, has provided valuable genetic data. Researchers generated genetic information for all participants, including exome sequencing for everyone and whole-genome sequencing for nearly 10,000 individuals. They discovered significant differences in…
An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption Haemoglobin, commonly known for carrying oxygen in red blood cells, has been discovered to play a significant role in chondrocytes, which are cells in cartilage. Chondrocytes produce large amounts of haemoglobin to create specialized structures called “haemoglobin bodies” (Hedy) within their cytoplasm. These bodies are…
The Unequal Consequences of Job Loss across Countries This study analyzed the effects of job loss in various countries using a consistent research approach with seven employer-employee datasets. Workers in Denmark and Sweden had the smallest earnings reduction after losing their jobs, whereas those in Italy, Spain, and Portugal experienced earnings losses three times greater….
Reducing Frictions in Health Care Access: The ActionHealthNYC Experiment for Undocumented Immigrants In 2016, New York City initiated a program aimed at making it easier for undocumented immigrants to access healthcare. They did this by randomly scheduling primary care appointments for 2,428 individuals. A unique data combination of surveys and administrative records revealed that this…
The Long-Run Impacts of Mexican American School Desegregation This study conducted a quantitative analysis to understand the impact of ending legal segregation of Mexican American schoolchildren in the United States, specifically focusing on the 1947 Mendez v. Westminster court decision. The study examined its effects on the long-term educational achievements of both Hispanic and non-Hispanic…
Global evidence of rapid urban growth in flood zones since 1985 This study reveals that human settlements worldwide, from small villages to large cities, have been rapidly expanding into areas prone to flooding since 1985. This expansion is happening more quickly in high-risk flood zones compared to safer areas, particularly in East Asia. These findings…
The Educational Consequences of Remote and Hybrid Instruction during the Pandemic This study analyzed data from over two million students in nearly 10,000 schools across 49 states and the District of Columbia to understand how remote and hybrid instruction affected educational achievement gaps related to race and school poverty. The study found that remote instruction…
Temporal Trends in Childhood Household Income Among Applicants and Matriculants to Medical School and the Likelihood of Acceptance by Income, 2014-2019 This study analyzed data on applicants and matriculants to US medical school programs between 2014 and 2019 to investigate trends in childhood household income among medical school applicants and its influence on acceptance rates….
Early Metformin in Gestational Diabetes This study aimed to determine whether early initiation of metformin could improve outcomes for gestational diabetes. The research found that early treatment with metformin did not significantly reduce the need for insulin initiation or improve fasting hyperglycemia. However, certain secondary outcomes, such as maternal glycemic control and gestational weight gain,…
Extracorporeal Life Support in Infarct-Related Cardiogenic Shock A multicenter trial examined the use of extracorporeal life support (ECLS) in patients with acute myocardial infarction complicated by cardiogenic shock. The study found that ECLS therapy did not significantly reduce the risk of death at 30 days compared to those who received medical therapy alone. However, ECLS…
