|

Revolutionizing Autoimmune Disease Treatment with CAR T Cells

ByThe Short Paper

CAR T-cell therapy in autoimmune diseases

For patients not responding to current autoimmune disease treatments, a promising approach involves using engineered T cells (CAR T cells) that target autoreactive B cells, which are responsible for diseases like lupus and arthritis. Recent studies using CD19 CAR T cells have shown rapid and sustained depletion of B cells, leading to clinical remission in diseases like lupus and dermatomyositis. This research explores these innovative strategies for targeted therapy in autoimmune diseases

Schett G, Mackensen A, Mougiakakos D. CAR T-cell therapy in autoimmune diseases. Lancet. 2023 Sep 22:S0140-6736(23)01126-1. doi: 10.1016/S0140-6736(23)01126-1. Epub ahead of print. PMID: 37748491.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01126-1/fulltext

Similar Posts

|

Worldwide ICU Blood Transfusion Practices Study

ByThe Short Paper

Red Blood Cell Transfusion in the Intensive Care Unit A global study conducted in 30 countries on six continents between March 2019 and October 2022 evaluated and described red blood cell (RBC) transfusion practices in 233 intensive care units (ICUs). Among 3,643 adult patients, 25% received one or more RBC transfusions during their ICU stay,…

|

Study on Dexamethasone for Tuberculous Meningitis in HIV Patients

ByThe Short Paper

This was a double-blind, randomized trial involving HIV-positive adults with tuberculous meningitis in Vietnam and Indonesia examined the effectiveness of dexamethasone, an anti-inflammatory drug, as an adjunct treatment. Participants received either dexamethasone or a placebo in addition to antituberculosis therapy. The study found that dexamethasone did not significantly improve survival rates or secondary outcomes, such…

|

Global Health and Economic Impact of Lead Exposure

ByThe Short Paper

Global health burden and cost of lead exposure in children and adults: a health impact and economic modelling analysis Despite significant reductions in lead exposure, it remains a global health threat. A recent study estimated the worldwide burden and cost of intelligence quotient (IQ) loss and cardiovascular disease mortality due to lead exposure. Findings revealed…

|

Unclaimed Bodies and Medical Education in Texas

ByThe Short Paper

The use of unclaimed bodies in US medical education, although declining, still occurs without consent from the deceased or their next of kin. This study aims to investigate the trends of unclaimed body usage in medical education specifically in Texas, shedding light on this underresearched practice. Shupe E, Karim S, Sledge D. Unclaimed Bodies and Medical Education…

|

Unlocking Genetic Diversity and Insights from the Mexico City Prospective Study

ByThe Short Paper

Genotyping, sequencing and analysis of 140,000 adults from Mexico City The Mexico City Prospective Study, consisting of over 150,000 adults from urban districts in Mexico City, has provided valuable genetic data. Researchers generated genetic information for all participants, including exome sequencing for everyone and whole-genome sequencing for nearly 10,000 individuals. They discovered significant differences in…

|

Revolutionary Injectable Prosthesis Speeds Up Tissue Repair

ByThe Short Paper

Injectable tissue prosthesis for instantaneous closed-loop rehabilitation Researchers have developed an innovative injectable tissue prosthesis made of a soft hydrogel combined with gold nanoparticles, allowing instantaneous bidirectional electrical conduction within the neuromuscular system. Unlike previous patch-type devices, this injectable prosthesis conforms to rough, narrow, or deep tissue surfaces. Tested in rats with severe muscle injury,…