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Revolutionizing Autoimmune Disease Treatment with CAR T Cells

ByThe Short Paper

CAR T-cell therapy in autoimmune diseases For patients not responding to current autoimmune disease treatments, a promising approach involves using engineered T cells (CAR T cells) that target autoreactive B cells, which are responsible for diseases like lupus and arthritis. Recent studies using CD19 CAR T cells have shown rapid and sustained depletion of B…

Boosting Immune Memory for Enhanced Cancer Therapy

ByThe Short Paper

Reductive carboxylation epigenetically instructs T cell differentiation Immune cells called CD8+ T cells play a crucial role in protecting the body from diseases like cancer by undergoing metabolic changes when activated. Researchers found that one specific metabolic process involving a mitochondrial enzyme called IDH2 affects the development of memory CD8+ T cells. Inhibiting IDH2 during…