Revolutionizing Autoimmune Disease Treatment with CAR T Cells

CAR T-cell therapy in autoimmune diseases

For patients not responding to current autoimmune disease treatments, a promising approach involves using engineered T cells (CAR T cells) that target autoreactive B cells, which are responsible for diseases like lupus and arthritis. Recent studies using CD19 CAR T cells have shown rapid and sustained depletion of B cells, leading to clinical remission in diseases like lupus and dermatomyositis. This research explores these innovative strategies for targeted therapy in autoimmune diseases

Schett G, Mackensen A, Mougiakakos D. CAR T-cell therapy in autoimmune diseases. Lancet. 2023 Sep 22:S0140-6736(23)01126-1. doi: 10.1016/S0140-6736(23)01126-1. Epub ahead of print. PMID: 37748491.


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