Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia This clinical trial investigated whether inhaled amikacin, an antibiotic, could reduce the incidence of ventilator-associated pneumonia in critically ill patients on mechanical ventilation for at least 3 days. The study included 847 patients who received either inhaled amikacin or a placebo for 3 days. Results showed that inhaled amikacin…
This was a double-blind, randomized trial involving HIV-positive adults with tuberculous meningitis in Vietnam and Indonesia examined the effectiveness of dexamethasone, an anti-inflammatory drug, as an adjunct treatment. Participants received either dexamethasone or a placebo in addition to antituberculosis therapy. The study found that dexamethasone did not significantly improve survival rates or secondary outcomes, such…
Extracorporeal Life Support in Infarct-Related Cardiogenic Shock A multicenter trial examined the use of extracorporeal life support (ECLS) in patients with acute myocardial infarction complicated by cardiogenic shock. The study found that ECLS therapy did not significantly reduce the risk of death at 30 days compared to those who received medical therapy alone. However, ECLS…
Remote Ischemic Conditioning for Acute Stroke: The RESIST Randomized Clinical Trial This study evaluated remote ischemic conditioning (RIC), a treatment involving cycles of limb ischemia and reperfusion, for acute stroke. Despite promising earlier data, the study found that RIC, when started in ambulances and continued in hospitals, did not significantly improve functional outcomes at 90…
One-time psilocybin treatment for depression A study investigated the effectiveness and safety of psilocybin, a compound found in certain mushrooms, for treating major depressive disorder. In a controlled trial with 104 adults, a 25-mg dose of psilocybin, when combined with psychological support, resulted in a significant and enduring improvement in depressive symptoms compared to a…
This study tested a new treatment called mezigdomide, combined with dexamethasone, for people with multiple myeloma (a type of cancer). The treatment showed promise in patients who had already tried other treatments, including those resistant to lenalidomide and pomalidomide. In the first phase of the study, they tested the treatment on 77 patients to determine…
This study looked at a treatment called ferric carboxymaltose for people with heart failure who also had low iron levels. They compared it to a placebo (a fake treatment) alongside standard heart failure therapy. The study involved over 3,000 patients. The results showed that there wasn’t a significant difference between the two groups in terms…
