|

Understanding the Impact of Blood Transfusions on Preterm Infants’ Health

ByThe Short Paper

Tissue Oxygenation Changes After Transfusion and Outcomes in Preterm Infants: A Secondary Near-Infrared Spectroscopy Study of the Transfusion of Prematures Randomized Clinical Trial (TOP NIRS)

This study investigates the effects of red blood cell (RBC) transfusions on preterm infants, focusing on tissue oxygen saturation responses. Conducted as a subset of the Transfusion of Prematures (TOP) trial, the research explores whether transfusions influence cerebral and mesenteric tissue saturation. Findings reveal a significant increase in cerebral and mesenteric saturation after transfusion, emphasizing potential benefits. However, lower pretransfusion cerebral saturation may be linked to adverse outcomes. The study highlights the need for targeted tissue saturation monitoring in anemic preterm infants and suggests associations between transfusion parameters and long-term health outcomes.

Chock VY, Kirpalani H, Bell EF, et al. Tissue Oxygenation Changes After Transfusion and Outcomes in Preterm Infants: A Secondary Near-Infrared Spectroscopy Study of the Transfusion of Prematures Randomized Clinical Trial (TOP NIRS). JAMA Netw Open. 2023;6(9):e2334889.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809782

Similar Posts

|

Evening Types Have Higher Diabetes Risk, Lifestyle Factors Play a Role

ByThe Short Paper

Chronotype, Unhealthy Lifestyle, and Diabetes Risk in Middle-Aged U.S. Women This study was conducted among 63,676 middle-aged nurses from 2009 to 2017. It found that nurses who identify as evening persons, or “night owls”, tend to have unhealthier lifestyles and are at a higher risk of diabetes than those who are morning persons, or “early…

|

Unlocking Genetic Diversity and Insights from the Mexico City Prospective Study

ByThe Short Paper

Genotyping, sequencing and analysis of 140,000 adults from Mexico City The Mexico City Prospective Study, consisting of over 150,000 adults from urban districts in Mexico City, has provided valuable genetic data. Researchers generated genetic information for all participants, including exome sequencing for everyone and whole-genome sequencing for nearly 10,000 individuals. They discovered significant differences in…

|

Socioeconomic Status Influences Medical School Acceptance Rates, Study Finds

ByThe Short Paper

Temporal Trends in Childhood Household Income Among Applicants and Matriculants to Medical School and the Likelihood of Acceptance by Income, 2014-2019 This study analyzed data on applicants and matriculants to US medical school programs between 2014 and 2019 to investigate trends in childhood household income among medical school applicants and its influence on acceptance rates….

|

Advancing Porcine Organs for Human Transplants: Successful Kidney Grafts in Monkeys

ByThe Short Paper

Design and testing of a humanized porcine donor for xenotransplantation Recent studies have explored the potential of using pig organs for human transplantation. Before moving to human trials, genetically engineered pig donors need to be created, and their organ transplants must be tested in nonhuman primates. In this study, researchers describe the development of kidney…

|

Mixed Outcomes Revealed in Early Metformin Treatment in Gestational Diabetes

ByThe Short Paper

Early Metformin in Gestational Diabetes This study aimed to determine whether early initiation of metformin could improve outcomes for gestational diabetes. The research found that early treatment with metformin did not significantly reduce the need for insulin initiation or improve fasting hyperglycemia. However, certain secondary outcomes, such as maternal glycemic control and gestational weight gain,…

|

Revolutionizing Autoimmune Disease Treatment with CAR T Cells

ByThe Short Paper

CAR T-cell therapy in autoimmune diseases For patients not responding to current autoimmune disease treatments, a promising approach involves using engineered T cells (CAR T cells) that target autoreactive B cells, which are responsible for diseases like lupus and arthritis. Recent studies using CD19 CAR T cells have shown rapid and sustained depletion of B…